2021 Mercedes-Benz CLS-Class 450 – Review, Specs, Configurations, Prices, and Interior
Table of Contents
Review
When the 2021 Mercedes-Benz CLS-Class 450 was first introduced, it pioneered the concept of the “four-door coupe,” and the five-seat mid-size sports car was last revised for 2019.
Power comes from a 3.0-liter inline-six turbocharged engine that produces 362 horsepower in the 2021 Mercedes-Benz CLS 450 rear- or all-wheel-drive and 429 hp in the 2021 Mercedes-Benz AMG CLS 53 performance-oriented all-wheel-drive.
There is a nine-speed automatic transmission in both trim models(rear-wheel-drive and all-wheel-drive 4MATIC). While the 2021 Mercedes-Benz CLS has a swooper exterior look and an interior design unique from the E, its back seat and trunk are less comfortable.
Its sportier version, the 2021 Mercedes-Benz-AMG CLS 53 (reviewed separately), is overmatched by the 2021 Mercedes-Benz CLS450, but it offers the entire class provided by the standard E-class sedan, plus slinky great looks.
For the 2021 Mercedes-Benz CLS 450, the EPA’s fuel economy forecasts are 23 mpg city and 30 mpg highway; adding all-wheel drive decreases those statistics to 22 mpg city and 29 mpg highway. These ratings mean that, with the Audi A7, which is rated at 22 mpg city and 29 highway, the Mercedes is neck-in-neck.
More details regarding the Features, Configurations, and Interior are described in the sections below. If you want to know about the 2021 Ford Mustang Mach-E, then click our post.
Specs and Features
Engine | I-6 |
Seating | 5 Passengers |
Power | 362 @ 5500 rpm |
Transmission | 9-spd auto w/OD |
MPG | 23 City / 30 Hwy |
Drivetrain | Rear-wheel Drive |
Price
The MSRP of the 2021 Mercedes-Benz CLS-Class 450 is ranging between $70,300 – $72,800.
What’s Newly Include in 2021
The new upgrades in the 2021 Mercedes-Benz CLS-Class 450 include the following features:
- The 2021 Mercedes-Benz CLS-Class gets the latest version of Mercedes’ MBUX multimedia system.

2021 Mercedes-Benz CLS-Class 450 Configurations
The different configurations of the 2021 Mercedes-Benz CLS-Class 450 are listed below:
1. Base (Rear-wheel-drive)
Price: The MSRP of the Base(Rear-wheel-drive) is $70,300.
Specs and Features: It comes with a 3.0L I-6 Engine, 9-spd auto w/OD, Transmission 362 @ 5,500 rpm, Horsepower 369 @ 1,600 rpm Torque, rear-wheel-drive type, ABS and driveline Traction control, 1st row regular express open/close sliding and tilting glass sunroof, 19″ machined w/painted accents aluminium wheels, front air conditioning, dual-zone automatic, driver and front passenger heated-cushion, heated-seatback heated front seats, AM/FM/HD, seek-scan radio, 2 – 1st row LCD monitor, keyfob (all doors) remote keyless entry heated mirrors, windshield wipers – rain-sensing, leather seat trim, driver and passenger Lumbar support, and MBUX with voice activation navigation system.
2. Base(All-wheel-drive 4MATIC)
Price: The MSRP of the Base(All-wheel-drive 4MATIC) is $72,800.
Specs and Features: It comes with a 3.0L I-6 Engine, 9-spd auto w/OD, Transmission 362 @ 5,500 rpm, Horsepower 369 @ 1,600 rpm Torque, ABS and driveline Traction control, 1st row regular express open/close sliding and tilting glass sunroof, 19″ machined w/painted accents aluminium wheels, front air conditioning, dual-zone automatic, driver and front passenger heated-cushion, heated-seatback heated front seats, AM/FM/HD, seek-scan radio, 2 – 1st row LCD monitor, keyfob (all doors) remote keyless entry, heated mirrors, windshield wipers – rain-sensing, leather seat trim, driver and passenger lumbar support, MBUX with voice activation navigation system, and 4MATIC all-wheel-drive type.

2021 Mercedes-Benz CLS-Class 450 Interior
In its cabin style, the polished planes and sloping lines of the exterior of the 2021 Mercedes-Benz CLS-class are mirrored. With an elegant swirl, the dash surrounds front-seat passengers, and a quartet of circular air vents occupies the middle stack.
The overall look of the cabin is premium and undeniably attractive with its Nappa leather upholstery. There’s seating for five, but for those seated in the rear, the car’s swooping roofline takes a toll on the headroom.
The 2021 Mercedes-Benz CLS-class offers Thirty-five inches of rear-seat legroom. That’s two inches less than the A7 you’re going to get.
There’s not a lot of room in the trunk, particularly considering Benz’s sizable footprint. Cargo capacity estimates a paltry 12 cubic feet of capacity; in contrast, the A7 serves up 25 cubic feet of space for your stuff.
The 2021 Mercedes-Benz CLS-class base model comes with Bluetooth phone networking and audio streaming. Furthermore, mobile integration for Apple CarPlay/Android Auto is on hand to help you connect your devices seamlessly.
A 12.3-inch screen and a touchpad controller are included in the infotainment system. A Wi-Fi hotspot, a head-up display and charging of wireless devices are included in the list of optional items.

Should I Buy a 2021 Mercedes-Benz CLS-Class 450?
The luxurious design has long become the calling card of the 2021 Mercedes-Benz CLS-Class, and that is no different in the latest iteration. Also, as you would expect from a Mercedes-Benz, it is comfortable, quiet, and luxurious. However, the backseat is small, and sometimes the automatic transmission upshifts too fast.
For more information about the latest Mercedes-Benz CLS-Class 450, kindly visit the Official Website.
You may also Ask for
Is the 2021 Mercedes-Benz CLS-Class 450 the right car?
It is, indeed. With powerful engines, a smooth ride, and competent handling, the 2021 Mercedes-Benz CLS-Class also works well. It is luxurious inside, too, and, despite the roofline, it has decent space. We rated it 7.2 out of 10 in total.
What is a 2021 Mercedes-Benz CLS-Class 450 worth?
With rear-wheel drive, the base 2021 Mercedes-Benz CLS450 costs $71,295 and comes fitted with navigation, leather upholstery, heated seats, and 19-inch wheels.
What does CLS mean for Mercedes?
“The Mercedes car “CLS” model stands for “coupe leicht sport”. It refers to the vehicle’s form of body and design.
How fast is the 2021 Mercedes-Benz CLS-Class 450?
In the Mercedes-Benz CLS450, the inline-6 generally produces 362 hp and 369 lb-ft of torque, when coupled with all-wheel drive, launches the car from 0-60 mph in 4.8 seconds. Moreover, the output is improved to 429 hp and 384 lb-ft of torque by the 2021 Mercedes-Benz CLS53 AMG, and the 0-60-mph run is cut to 4.3 seconds. Naturally, power comes on without an early wave or late peak.